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Non-Hodgkin's Lymphoma

About

Non-Hodgkin lymphoma is an uncommon cancer that develops in the lymphatic system, which is a network of vessels and glands spread throughout your body.

The lymphatic system is part of your immune system. Clear fluid called lymph flows through the lymphatic vessels and contains infection-fighting white blood cells known as lymphocytes.

In non-Hodgkin lymphoma, the affected lymphocytes start to multiply in an abnormal way and begin to collect in certain parts of the lymphatic system, such as the lymph nodes (glands). The affected lymphocytes lose their infection-fighting properties, making you more vulnerable to infection.

The most common symptom of non-Hodgkin lymphoma is a painless swelling in a lymph node, usually in the neck, armpit or groin. 

Read more about the symptoms of non-Hodgkin lymphoma

Who's affected?

In the UK, more than 12,000 people are diagnosed with non-Hodgkin lymphoma each year.

Non-Hodgkin lymphoma can occur at any age, but your chances of developing the condition increase as you get older, with most cases diagnosed in people over 65. Slightly more men than women are affected.

What causes non-Hodgkin lymphoma?

The exact cause of non-Hodgkin lymphoma is unknown. However, your risk of developing the condition is increased if:

  • you have a medical condition that weakens your immune system
  • you take immunosuppressant medication
  • you've previously been exposed to a common virus called the Epstein-Barr virus  which causes glandular fever

You also have a slightly increased risk of developing non-Hodgkin lymphoma if a first-degree relative (such as a parent or sibling) has had the condition.

Read more about the causes of non-Hodgkin lymphoma.

How non-Hodgkin lymphoma is diagnosed

The only way to confirm a diagnosis of non-Hodgkin lymphoma is by carrying out a biopsy.

This is a minor surgical procedure where a sample of affected lymph node tissue is removed and studied in a laboratory.

Read more about diagnosing non-Hodgkin lymphoma.

Treatment and outlook

There are many subtypes of non-Hodgkin lymphoma, but they can generally be put into one of two broad categories:

  • high-grade or aggressive non-Hodgkin lymphoma  where the cancer develops quickly and aggressively
  • low-grade or indolent non-Hodgkin lymphoma  where the cancer develops slowly, and you may not experience any symptoms for many years

The outlook for non-Hodgkin lymphoma varies greatly, depending on the exact type, grade and extent of the lymphoma, and the person’s age.

Low-grade tumours don't necessarily require immediate medical treatment, but are harder to completely cure. High-grade lymphomas need to be treated straight away, but tend to respond much better to treatment and can often be cured. 

The main treatments used for non-Hodgkin lymphoma are:

Overall, most cases of non-Hodgkin lymphoma are considered very treatable. You can read more detailed information about the outlook for non-Hodgkin lymphoma on the Cancer Research UK website.

However, there's a risk of long-term problems after treatment, including infertility and an increased risk of developing another type of cancer in the future.

Read more about: 

Information about you

If you have non-Hodgkin lymphoma, your clinical team will pass information about you on to the National Congenital Anomaly and Rare Diseases Registration Service (NCARDRS).

This helps scientists look for better ways to prevent and treat this condition. You can opt out of the register at any time.

Find out more about the register.



Further information on non-Hodgkins lymphoma

Information Prescription Service

To access the Information Prescription Service and the national cancer information pathway for Non-Hodgkin's Lymphoma please click on the link below. Then click on 'Specialist information from our charity partners'

www.nhs.uk

Macmillan Cancer Support Website

www.macmillan.org.uk

Cancer Research UK Website

www.cancerresearchuk.org

Further Information

Visit or phone a local cancer information centre

There are several cancer information and support centres in Essex Cancer Network where anyone affected by cancer can be sure of a warm welcome and high quality, accurate, evidence-based information:

Basildon Hospital Macmillan Info and Support Centre, Outpatients Dept, Basildon Hospital, staffed Monday 2pm - Friday 12.30pm,tel: 0845 155 3111 extension 4908

Macmillan Info and Support Centre,Essex County Hospital, Outpatients Dept, Monday - Friday office hours, tel: 01206 747474

Information Resource Service, St Luke's House, Corringham,Thurrock, Monday to Friday office hours, tel: 01375 648170

Lantern Suite, Farleigh Hospice,Chelmsford, Monday to Friday office hours, tel: 01245 457418

Hospice Outreach Project Information Bus, Farleigh Hospice, covers the Chelmsford area. Contact Farleigh Hospice as above

For more information, please contact the service direct.

 

Visit your local library in Essex Cancer Network

Essex, Southend and Thurrock library services have worked in partnership with Macmillan Cancer Support and the Essex Cancer Network to establish collections of quality assured information books and pamphlets about cancer. These can be accessed at any library: just ask. Additionally some staff at libraries have been trained to help patients use the Information Prescription Service.

Contact Macmillan Cancer Support Helplines

If you have any questions about cancer, need support or just someone to talk to, call free, Monday to Friday 9am - 8pm (interpretation service available) tel: 0808 808 0000

For financial queries tel: 0808 808 2232

 

Remember: Stay safe online when looking for support!

Internet chat rooms and message forums can be valuable sources of support and comfort, enabling you to meet others in the same position. However, there is potential for abuse - please read these guidelines before you set off to explore...

Click here to download the draft guidelines

 

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